Researchers at the Institute for Stem Cell Therapy and Exploration of Monogenic Diseases (I-Stem – Inserm/AFM/UEVE), in collaboration with the Centre National de la Recherche Scientifique (CNRS) and Paris Descartes University, have recently developed a new method to control the differentiation of human pluripotent stem cells. The new method allows for greater control of this process, which enables the production of different populations of motor neurons from these cells in only 14 days, nearly twice as fast as older techniques. Published in Nature Biotechnology, this discovery will lead to greater progress in the understanding of diseases that affect motor neurons such as infantile spinal amyotrophy or amyotrophic lateral sclerosis (ALS), better known by some as Motor Neurone Disease.

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